This study is a secondary analysis study using the raw data of the 8th National Health and Nutrition Survey (2019), and a descriptive survey study to identify the factors affecting the health-related quality of life of middle-aged men, which can be seen as a crisis in an individual's life. The total number of subjects in this study was 8,110, 3,729 men, 1,340 subjects aged 40 to 64, and 1,037 final subjects excluding missing values. The collected data were analyzed by a complex sample analysis method using stratification, colony, and weight using SPSS/WIN 24.0. Research Results Job (B=.727, p<.001), economic level (B=1.260, p=017), subjective health consciousness (B=.276, p<.001), Stress (B=1.687, p<.001) was found to be a factor that had a significant effect on health-related quality of life. Therefore, this study aims to provide basic data on the development of programs to improve health-related quality of life by identifying the factors affecting health-related quality of life of middle-aged men.