The purpose of this study is to identify nursing students' college life stress, family strengths and to identify factors that affect the quality of life of nursing students. Data were collected from 200 nursing students between April 20th to May 24th, 2018 from a college in A city. Data were analyzed using descriptive statistics, t-tests, a one-way ANOVA, Pearson correlation, and multiple regression. All analyzes were conducted using IBM SPSS 22.0. The results of the multiple regression analysis showed that the regression model was significant (F=14.57, p<.001). The factors affecting the quality of life were family strengths (β=.36, p<.001), high satisfaction in university (β=.30, p=.002), college life stress (β=-.20, p=.002). This regression model was explained by 41% of variances in the quality of life of nursing students. To enhance the quality of life of nursing students it is necessary to analyze college life stress and to assess family strength to relieve stress. In addition, universities need to make efforts to improve overall nursing students' satisfaction with the university by investing and providing continuous support for education and facilities that meet the demands of students.